• 1980 – 1984??? 北京師范大學(xué)生物系學(xué)士?
  1985 – 1990??? 美國德州西南醫(yī)學(xué)中心生物化學(xué)與分子生物學(xué)博士
  
  
• 1990 – 1992??? 美國德州西南醫(yī)學(xué)中心生物化學(xué)系，博士后
  1992 – 1994??? 美國肯塔基大學(xué)生物化學(xué)系，助理研究教授
  1994 – 1998?? ?美國肯塔基大學(xué)生物化學(xué)系，助理教授
  1998 – 2004?? ?美國佛羅里達大學(xué)藥學(xué)院藥物化學(xué)系，助理教授
  2004 – 至今???? 中國科學(xué)院廣州生物醫(yī)藥與健康研究院，研究員????

• 1.脂肪細胞褐色化機理研究：包括褐色脂肪細胞和beige脂肪細胞的分化機理研究以及白色脂肪向褐色脂肪細胞和beige脂肪細胞轉(zhuǎn)分化研究。?2.白色脂肪細胞分化的機理研究：包括生理條件下白色脂肪細胞分化分化的分子機理研究，以及其他來源的細胞向白色脂肪細胞轉(zhuǎn)分化的研究。?3.脂肪酸代謝的分子研究：利用基因敲除、轉(zhuǎn)基因小鼠等動物模型，研究長鏈脂肪酸的代謝情況在各個器官中的作用。?

• 2004CB720102???? 973計劃???????????????????????????????????????????? 與疾病相關(guān)抗體的結(jié)構(gòu)與功能研究
• 30670457?????????????? 國家自然科學(xué)基金??????????????????????????? 肉堿棕櫚酰轉(zhuǎn)移酶1c的功能研究
• 30710527??????????????國家自然科學(xué)基金國際合作項目????? 肉堿棕櫚酰轉(zhuǎn)移酶1c對脂肪細胞因子的調(diào)控研究
• 30810099??????????????國家自然科學(xué)基金國際合作項目????? APPL1介導(dǎo)脂聯(lián)素心臟保護作用的功能研究
• 2007Z2-E4021??????廣州市科技計劃????? ?????????????????????????? CPT1-A轉(zhuǎn)基因小鼠的構(gòu)建和代謝疾病研究
• ?????????????????????????????????中國科學(xué)院院地合作項目??????????????? ? 廣東省生物醫(yī)藥產(chǎn)業(yè)發(fā)展瓶頸與對策研究

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1. L. Mao, W. Lin, T. Nie, X. Hui, X. Gao, K. Li, M. Ding, X. Tang, P. Li, Y. Wang, A. Xu, P. Liu, and D. Wu (2014). Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci 4, 60.
2. K. K. Cheng, W. Zhu, B. Chen, Y. Wang, D. Wu, G. Sweeney, B. Wang, K. S. Lam, and A. Xu (2014). The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes.
3. X. Li, L. Wang, X. E. Zhou, J. Ke, P. W. de Waal, X. Gu, M. H. Tan, D. Wang, D. Wu, H. E. Xu, and K. Melcher (2014). Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res.
4. Song Yang, Ye Kuang, Hongbo Li, Yuehong Liu, Xiaoyan Hui, Peng Li, Zhiwu Jiang, Yulai Zhou, Yu Wang, Aimin Xu, Shiwu Li, Pentao Liu, and Donghai Wu (2013). Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site. Plos One 8.
5. Nie, T., Hui, X., Gao, X., Li, K., Lin, W., Xiang, X., Ding, M., Kuang, Y., Xu, A., Fei, J., et al. (2012). Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett.
6. Lin, W., Huang, X., Zhang, L., Chen, D., Wang, D., Peng, Q., Xu, L., Li, J., Liu, X., Li, K., et al. (2012). BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS One 7, e44570.
7. Bai, B., Liang, Y., Xu, C., Lee, M.Y., Xu, A., Wu, D., Vanhoutte, P.M., and Wang, Y. (2012). Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126, 729-740.
8. Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F.G., Moran, T.H., and Lopaschuk, G.D. (2011). Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A 108, 9691-9696.
9. Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., and Wu, D. (2011). Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J 435, 723-732.
10. Hui, X., Li, H., Zhou, Z., Lam, K.S., Xiao, Y., Wu, D., Ding, K., Wang, Y., Vanhoutte, P.M., and Xu, A. (2010). Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem 285, 10273-10280.
11. Wen, L., Liu, J., Chen, Y., and Wu, D. (2010). Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. Biochem Biophys Res Commun 396, 419-424.
12. Zhou, M., Xu, A., Lam, K.S., Tam, P.K., Che, C.M., Chan, L., Lee, I.K., Wu, D., and Wang, Y. (2010). Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol 53, 1108-1116.
13. Gao, Y., Zhou, Y., Xu, A., and Wu, D. (2008). Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells. Biol Pharm Bull 31, 1716-1722.
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