實(shí)驗(yàn)室（更多內(nèi)容見實(shí)驗(yàn)室主頁https://jiewanglab.github.io/us/index.html）以多組學(xué)檢測(cè)、生物信息學(xué)分析結(jié)合實(shí)驗(yàn)驗(yàn)證的交叉手段，研究疾病發(fā)生與器官再生的調(diào)控機(jī)制，主要涉及以下研究?jī)?nèi)容：

1. 檢測(cè)類器官等損傷修復(fù)模型的多組學(xué)圖譜，并開發(fā)新算法分析組學(xué)數(shù)據(jù)。

2. 多組學(xué)分析結(jié)合功能實(shí)驗(yàn)揭示疾病發(fā)生與器官再生的表觀調(diào)控機(jī)制。

3.?構(gòu)建調(diào)控疾病發(fā)生與器官再生的數(shù)字模型，發(fā)現(xiàn)有效的基因干預(yù)靶點(diǎn)。

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課題組圍繞疾病發(fā)生和器官再生相關(guān)的表觀組，開發(fā)了組學(xué)整合、調(diào)控網(wǎng)絡(luò)重構(gòu)等新方法，揭示了神經(jīng)退化和再生修復(fù)的表觀調(diào)控圖譜，并部分實(shí)現(xiàn)了哺乳動(dòng)物的視網(wǎng)膜再生。在Science, Nature Communications, Briefings in Bioinformatics等雜志發(fā)表多篇研究論文，包括2篇ESI高被引論文。（#共同第一作者，*共同通訊作者）

1. Hoang T^#, Wang J^#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR^*, Qian J^*, Blackshaw S^*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 2020, 370(6519):?eabb8598.
2. Wang J^#, Zibetti C^#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S,?Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S^*, Qian J^*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications?2018, 9(1): 1-13.
3. Jiang J^#, Li J^#, Huang S, Jiang F, Liang Y, Xu X^*, Wang J^*. CACIMAR:?cross-species analysis of cell identities, markers, regulations, and interactions using single-cell RNA sequencing data. Briefings in Bioinformatics?2024, 25(1):?bbae283.
4. Fu Y^#, Jiang F^#, Zhang X, Pan Y, Xu R, Liang X, Wu X, Li X, Lin K, Shi R, Zhang X, Ferrandon D, Liu J, Pei D, Wang J^*,?Wang T^*.?Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging. Nature Communications?2024, 15(1): 1-21.
5. Jiang J^#, Lyu P^#, Li J^#, Huang S, Tao J, Blackshaw S, Qian J, Wang J^*.?IReNA: integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience?2022, 25(11): 105359.

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