| DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1 |
Xuecong Wang,Yogesh Srivastava,Aleksander Jankowski，Vikas Malik,Yuanjie Wei, Ricardo CH del Rosario,Vlad Cojocaru, Shyam Prabhakar,Ralf Jauch |
2018 Jun; |
Nucleic Acids Research |
| Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems |
Han Wu, Qishuai Liu,Hui Shi,Jingke Xie, Quanjun Zhang,Zhen Ouyang, Nan Li,Yi Yang, Zhaoming Liu,Yu Zhao, Chengdan Lai,Degong Ruan,Jiangyun Peng,Weikai Ge,Fang bing Chen,Nana Fan,Qin Jin,Yanhui Liang,Ting Lan, Xiaoyu Yang,Xiaoshan Wang,Zhiyong Lei,Pieter A. Doevendans,Joost P. G. Sluijter,Kepin Wang,Xiaoping Li,Liangxue Lai |
2018 Oct; |
Cellular and Molecular Life Sciences |
| Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate |
Dengke Li,Tingting Mao,Jibo Huang,Qiang zhu |
2018 Sep; |
Journal of Organic Chemistry |
| The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming |
Lilong Lin,Lining Liang,Xiao Yang,Hao Sun,Yuan Li,Duanqing Pei,Hui Zheng |
2018 Sep; |
Journal of Biological Chemistry |
| Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin |
Dongsheng Zhu,Haijun Guo,Yu Chang,Yun Ni,Lin Li,Zhi-Min Zhang,Piliang Hao,Yong Xu,Ke Ding,Zhengqiu Li. |
2018 Jul; |
Angewandte Chemie-International Edition |
| An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques |
Yupeng Feng，Chufang Li，Peiyu Hu，Qian Wang，Xuehua Zheng，Yongkun Zhao，Yi Shi，Songtao Yang，Changhua Yi，Ying Feng，ChunxiuWu，Linbing Qu，WeiXu，YaoLi，CaijunSun，F(xiàn)uGerogeGao，XianzhuXia，Liqiang Feng，Ling Chen |
2018 Jun; |
Emerging Microbes & Infections |
| ATAD2 in cancer: a pharmacologically challenging but tractable target |
Muzammal Hussain,Yang Zhou,Yu Song,H.M. Adnan Hameed,Hao Jiang,Yaoquan Tu,Jiancun Zhang |
2018 Jan; |
Expert Opinion on Therapeutic Targets |
| Design,synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents |
Cai Lin, Jianchen Yu, Muzammal Hussain, Yiqian Zhou, Anna Duan, Weiqi Pan,Jie Yuan, Jiancun Zhang |
2018 Jan; |
Antiviral Research |
| Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5- d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors |
Qiuju Xun,Zhang Zhang,Jinfeng Luo,Linjiang Tong,Minhao Huang, Zhen Wang,Jian Zou, Yingqiang Liu,Yong Xu, Hua Xie,Zheng-Chao Tu, Xiaoyun Lu,Ke Ding |
2018 Mar; |
Journal of Medicinal Chemistry |
| Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer |
Xiaoqian Xue,Yan Zhang,Chao Wang,Maofeng Zhang,Qiuping Xiang,Junjian Wang,Anhui Wang, Chenchang Li,Cheng Zhang,Lingjiao Zou,Rui Wang,Shuang Wu,Yongzhi Lu,Hongwu Chen,Ke Ding, Guohui Li,Yong Xu |
2018 May; |
European Journal of Medicinal Chemistry |
| Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer |
Qiuping Xiang,Chao Wang,Yan Zhang, Xiaoqian Xue, Ming Song,Cheng Zhang, Chenchang Li, Chun Wu,Kuai Li,Xiaoyan Hui,Yulai Zhou,Jeff B. Smaill,Adam V. Patterson,Donghai Wu,Ke Ding,Yong Xu |
2018 Mar; |
European Journal of Medicinal Chemistry |
| Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).Journal of Medicinal Chemistry |
Maofeng Zhang, Yan Zhang, Ming Song, Xiaoqian Xue, Junjian Wang, Chao Wang, Cheng Zhang, Chenchang Li, Qiuping Xiang, Lingjiao Zou, Xishan Wu, Chun Wu, Baijun Dong, Wei Xue, Yulai Zhou, Hongwu Chen, Donghai Wu, Ke Ding,Yong Xu |
2018 Apr; |
Journal of Medicinal Chemistry |
| PCGF5 is required for neural differentiation of embryonic stem cells |
Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li,Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun,Huating Wang,Hongjie Yao |
2018 May; |
Nature Communications |
| Pd-Catalyzed Divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates |
Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li,Qiang Zhu |
2018 Apr; |
Organic Letters |
| Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions |
Shuang Luo,Zhuang Xiong,Yongzhi Lu,Qiang Zhu |
2018 Apr; |
Organic Letters |
| Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency |
Shangtao Cao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang, Yuanbang Mai, Yue Qin, Jian Wu, Jiangping He, Chunhua Zhou, He Liu, Bentian Zhao, Xiaodong Shu, Chuman Wu, Ruiping Chen, Waiyee Chan, Guangjin Pan, Jiekai Chen, Jing Liu, Duanqing Pei |
2018 Apr; |
Cell Stem Cell |
| A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease |
Sen Yan, Zhuchi Tu, Zhaoming Liu, Nana Fan, Huiming Yang, Su Yang, Weili Yang, Yu Zhao, Zhen Ouyang, Chengdan Lai, Huaqiang Yang, Li Li, Qishuai Liu, Hui Shi, Guangqing Xu, Heng Zhao, Hongjiang Wei, Zhong Pei, Shihua Li, Liangxue Lai, Xiao-Jiang Li |
2018 May; |
Cell |
| NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming |
Qiang Zhuang, Wenjuan Li, Christina Benda, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P. Iba？ez, Zhiwei Luo, Meng Zhang, Mazid Md. Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad Jadoon Khan, Shahzina Kanwal, Bushra Mirza, Micky D. Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins ,Miguel A. Esteban |
2018 Apr; |
Nature Cell Biology |
| A divergent and concise total synthesis of (-)-lycoposerramine R and (+)-lycopladine A |
Sheng Chen,Jinming Wang,Fayang G.Qiu |
2018 Apr; |
Chemical Communications |
| Proteome-wide identification of ubiquitin interactions using UbIA-MS |
Xiaofei Zhang,Arne H Smits,Gabrielle BA van Tilburg,Huib Ovaa,Wolfgang Huber,Michiel Vermeulen |
2018 Mar; |
Nature Protocols |
| Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes |
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao, Cui Lv, Ying Wang, Chengxiang Xia, Qitong Weng, Xiaofei Liu, Chen Li, Peiqing Zhou, Tongjie Wang, Yuxian Guan, Rongqun Guo, Lijuan Liu, Yang Geng, Hongling Wu, Juan Du, Zheng Hu, Sheng Xu, Jiekai Chen, Aibin He, Bing Liu, Demin Wang, Yong-Guang Yang,Jinyong Wang |
2018 Mar; |
Nature Immunology |
| Capturing the interactome of newly transcribed RNA |
Xichen Bao, Xiangpeng Guo, Menghui Yin, Muqddas Tariq, Yiwei Lai, Shahzina Kanwal, Jiajian Zhou, Na Li, Yuan Lv, Carlos Pulido-Quetglas, Xiwei Wang, Lu Ji, Muhammad J Khan, Xihua Zhu, Zhiwei Luo, Changwei Shao, Do-Hwan Lim, Xiao Liu, Nan Li, Wei Wang, Minghui He, Yu-Lin Liu, Carl Ward, Tong Wang, Gong Zhang, Dongye Wang, Jianhua Yang, Yiwen Chen, Chaolin Zhang, Ralf Jauch, Yun-Gui Yang, Yangming Wang, Baoming Qin, Minna-Liisa Anko, Andrew P Hutchins, Hao Sun, Huating Wang, Xiang-Dong Fu, Biliang Zhang,Miguel A Esteban |
2018 Mar; |
Nature Methods |
| Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs |
Wangfang Ping, Jian Hu, Gongcheng Hu, Yawei Song, Qing Xia, Mingze Yao, Shixin Gong, Cizhong Jiang,Hongjie Yao |
2018 Feb; |
Cell Death & Disease |
| Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition |
Zhenghui Su, Yanqi Zhang, Baojian Liao, Xiaofen Zhong, Xin Chen, Haitao Wang, Yiping Guo, Yongli Shan, Lihui Wang, Guangjin Pan |
2018 Mar; |
Journal of Biological Chemistry |
| XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer |
Degong Ruan, Jiangyun Peng, Xiaoshan Wang, Zhen Ouyang,Qingjian Zou,Yi Yang,Fangbing Chen,Weikai Ge, Han Wu,Zhaoming Liu,Yu Zhao, Bentian Zhao,Quanjun Zhang,Chengdan Lai,Nana Fan,Zhiwei Zhou, Qishuai Liu,Nan Li,Qin Jin, Hui Shi, Jingke Xie,Hong Song, Xiaoyu Yang,Jiekai Chen,Kepin Wang,Xiaoping Li,Liangxue Lai |
2018 Feb; |
Stem Cell Reports |
| Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma |
Yiling Zhang,Ying Feng,Liang Li,Xianmiao Ye,Jinlin Wang,Qian Wang,Pingchao Li,Na Li,Xuehua Zheng,Xiang Gao,Chufang Li,Feng Li,Baoqing Sun,Kefang Lai,Zhong Su,Nanshan Zhong,Ling Chen,Liqiang Feng |
2018 Apr; |
Journal of Molecular Medicine |
| CD215+ Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression |
Shouheng Lin, Guohua Huang, Yiren Xiao, Wei Sun, Yuchuan Jiang, Qiuhua Deng, Muyun Peng, Xinru Wei, Wei Ye, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Duanqing Pei, Fenglei Yu, Zhesheng Wen, Yao Yao, Donghai Wu,Peng Li |
2017 Dec; |
Frontier in Immunology |
| Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia |
Zhiwu Jiang, Di Wu, Wei Ye, Jianyu Weng, Peilong Lai, Pengcheng Shi, Xutao Guo, Guohua Huang, Qiuhua Deng, Yanlai Tang, Hongyu Zhao, Shuzhong Cui, Simiao Lin, Suna Wang, Baiheng Li, Qiting Wu, Yangqiu Li, Pentao Liu, Duanqing Pei, Xin Du, Yao Yao,Peng Li |
2017 Nov; |
Oncotarget |
| 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors |
Xueqiang Li，Christopher P.Guise,Rana Taghipouran,Yuliana Yosaatmadja,Amir Ashoorzadeh,Woo-Kyong Paik,Christopher J.Squire,Shuang Jiang ,Jinfeng Luo,Yong Xu,Zheng-Chao Tu,Xiaoyun Lu,Xiaomei Ren,Adam V.Patterson,Jeff B.Smaill,Ke Ding |
2017 Jul; |
European Journal of Medicinal Chemistry |
| Chromatin Accessibility Dynamics during iPSC Reprogramming |
Dongwei Li,Jing Liu,Xuejie Yang,Chunhua Zhou,Jing Guo,Chuman Wu,Yue Qin,Lin Guo,Jiangping He,Shenyong Yu,He Liu,Xiaoshan Wang,Fang Wu, Junqi Kuang,Andrew P. Hutchins, Jiekai Chen,Duanqing Pe |
2017 Dec; |
Cell Stem Cell |
